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the pigmentation may be homogeneously distributed or darker bands may appear over diffuse pale pigmentation (Figure 6)

Q., Wang Z., Shih D

The structural modification substituting a hydroxyl group where MT-II carries an amide was designed during Palatin Technologies' development program to concentrate therapeutic effects at MC3R and MC4R while stripping out the tanning and dermatological risk that come with strong MC1R agonism

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First, structure Melanotan 1 is a linear tridecapeptide while Melanotan 2 is a cyclic heptapeptide, with the cyclic constraint conferring substantially higher receptor binding affinity and potency