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These changes were not due to the limitations of the Langendorff mouse heart model as we found comparable results on analysing in vivo ischaemia in the heart using the left anterior artery, descending (LAD) occlusion model (Supplementary Fig

Some mitochondria showed a reduced number of cristae and altered cristae structure in the muscles of adult Drosophila harboring CHCHD2 mutations (Liu et al., 2020)

Furthermore, acyl glucuronides are not only able to directly acylate cellular proteins, but they can also transacylate the cysteine thiol of glutathione (GSH), leading to drug-Sacyl- GSH, which in turn is a highly reactive species [5]

Further analysis suggested that the adipose tissues of the AOD 9604 peptide animals had increased lipolytic activity and no marked insulin sensitivity interruption in the animals

262 PLGA-based delivery system is qualified to encapsulate a wide range of therapeutic cargos including small-molecule drugs, genes, proteins, vaccines, ensuring high bioavailability by protecting them from degradation

The major advantage of MC2753 over NBDHEX is that the hydrophobicity of the side chain strongly affects the interaction between MC2753 and GSTP1 and does not require GSH to trigger the dissociation of the GSTP1-TRAF2 complex