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In the SURMOUNT-1 trial, tirzepatide produced average weight loss of 15-22.5% of body weight over 72 weeks depending on dose

The disconnect between preclinical efficacy and human clinical outcomes remains unexplained and represents a significant limitation for potential therapeutic applications

This metabolic safety profile makes AOD-9604 potentially suitable for individuals with metabolic syndrome or diabetes risk factors who might not tolerate traditional growth hormone therapy, though medical supervision remains appropriate

Split dosing: Some practitioners split the daily dose into 250 mcg AM and 250 mcg pre-sleep on the rationale that two smaller pulses maintain steadier receptor exposure

Endocrinology, 142(12), 5182-5189

[DOI] [PubMed] [Google Scholar] 189.Bryzgalova G, Effendic S, Khan A, et al