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In addition, -KG is exported from mitochondria through SLC25A11 to the cytosol 21 and then participates in fatty acid biosynthesis and NADH generation 22 (Fig

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Curcumin may demethylate tumor-suppressor genes in cancer cells but also suppress inflammatory-gene promoters in immune cells, reflecting tissue-specific signaling crosstalk rather than a uniform epigenetic mechanism (Reuter et al., 2011)