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Mast Cell Activation Syndrome Treatment Conventional treatment for mast cell activation syndrome generally involves the use of pharmaceutical and over-the-counter medications to alleviate symptoms, such as the following medications: Epinephrine (such as an EpiPen) for severe reactions First generation H1 blockers diphenhydramine (Benadryl) and hydroxyzine (Vistaril) Second generation H1 blockers, including loratadine (Claritin), cetirizine (Zyrtec), and fexofenadine (Allegra) H2 blockers, such as ranitidine (Zantac) and famotidine (Pepcid) Aspirin, to block production of prostaglandin D2 and reduce flushing

Silpa-Archa N, Kohli I, Chaowattanapanit S, Lim HW, Hamzavi I

doi: 10.1186/S12937-025-01193-7 119

doi: 10.1016/j.virol.2009.07.038 77 MandhareM

Additionally, cytochrome B5 reductase (CYB5R1) and cytochrome P450 reductase (POR) contribute to the process of ferroptosis by accelerating the peroxidation of phospholipids (Zou et al., 2020b)

Sterility Check Ensures the medication is free from bacteria, fungi, and other contaminants