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A landmark 2021 study by Hong et al

Several HDT drugs used in the treatment of TB, including statins, macrocyclic lactones, and TKI, have received approval by the US Food and Drug Administration for other clinical applications, underscoring their favorable safety profiles

Mice lacking the modifier subunit of GCL, have a 60% reduction in glutathione, accompanied by abnormal cortical gamma synchrony, decreased parvalbumin interneurons (PV-IN) and behavioral phenotypes relevant to schizophrenia.(49-51)

Active site residues U46, K48, Q81, and W136 are highlighted and shown as sticks

injections with a dose of 100 nmol kg 1 of the experimental compounds

As a result, dendritic cells in the tumor microenvironment become less effective in stimulating antitumor immunity (77)