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Core and diverse additional symptoms, which can persist for years, exhibiting periods of relapses and remissions, usually start suddenly after an apparently common infection

In addition to LPS, gut-derived metabolites such as short-chain fatty acids (SCFAs) can influence BBB function, with certain SCFAs promoting anti-inflammatory pathways that protect the integrity of the BBB (Ahmed et al., 2022)

The analysis showed high between-group heterogeneity across the studies, but subgroup analyses detected that only studies comprising individuals with MCI had a significant effect of probiotics supplementation on improving cognitive function [88]

Jan 2017;42(1):254-270

They increase the expression of genes related to oxidative stress resistance and decrease the expression of genes linked to inflammatory and oxidation pathways

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