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doi:10.3109/19390211.2014.901999 Engber, D
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This phase 2 study compared brodalumab against placebo in patients with active PsA (both non-exposed and exposed to prior biologic therapy) to a primary endpoint of 20% improvement of American College of Rheumatology (ACR) criteria at week 12
Sun exposure, smoking, and stress can reverse the effects

This includes: The S0 category prohibits any pharmacological substance with no current approval by any governmental regulatory health authority for human therapeutic use