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(2014) 349:g4643

It is dosed between 300 mcg and 1,000 mcg (1 mg) daily, either subcutaneously or via an intranasal applicator

This may explain why side effects are relatively rare compared to pharmaceutical approaches that introduce foreign signaling molecules

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Senescent cells accumulate over time, meaning that senolytic treatment may need to be repeated periodically, raising concerns about chronic drug administration and potential cumulative side effects.122 Variability in Response and Individual Differences: Senescence is influenced by genetic factors, lifestyle, and environmental exposures, meaning that not all individuals may respond equally to senolytic therapy.123 Age-related changes in metabolism and drug clearance could also impact the effectiveness and safety of senolytics in older adults.124 Dosing and Treatment Scheduling: Determining the ideal dose and treatment schedule for senolytic therapies is complex