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153155 Also, the histone acetylation pattern is altered in GBM cells and has been linked to tumor aggressiveness, as shown by the findings that HDAC1, 2, and 3 are critical for the etiology of gliomas

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PEGylation, the covalent binding of polyethylene glycol (PEG), creates a hydrophilic steric shield that decreases protein adsorption and enhances circulation half-life [164]

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