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Pool of Seven Controlled Clinical Trials Adverse reactions were also evaluated in a larger pool of adult patients with type 2 diabetes mellitus participating in seven controlled clinical trials which included two placebo-controlled trials (SURPASS-1 and -5), three trials of MOUNJARO in combination with metformin, sulfonylureas, and/or SGLT2 Inhibitors (SURPASS-2, -3, -4) [see Clinical Studies (14.3)] and two additional trials conducted in Japan

doi: 10.3390/cells9051102 22 YoonTKLeeCHKwonOKimMS

Several environmental factors have been shown to induce oxidative stress on the ocular surface

doi: 10.2337/db15-0422 78 MillerDJCascioMARoscaMG

It presents with oculocutaneous albinism, peripheral neuropathy, and recurrent pyogenic infections

Although many of the VacA-mediated effects either directly or indirectly result from membrane binding and pore formation, VacA also enters the cytosol, subsequently accumulates in the mitochondrial inner membrane, and activates endogenous mitochondrial channels, thereby inducing apoptosis (105, 212, 329, 691)