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Vogelzangs N, Beekman AT, van Reedt Dortland AK, Schoevers RA, Giltay EJ, de Jonge P, Penninx BW

Chisalita, S

injections of 100 nmol kg 1 GLP-1 ( n = 6 mice), 100 nmol kg 1 GLP-1MK-801 (Pen-linked) ( n = 6 mice) or vehicle (isotonic saline, n = 6 mice) for 7 days

When to seek medical help See a doctor promptly if you have spreading redness or warmth around the site, discharge or a fever, numbness or weakness that does not settle, or any swelling of the face, lips or throat or difficulty breathing, which can signal a rare allergic reaction and is a medical emergency

Figure 1 shows a simple model of GSNO metabolism and its interactions with other molecules in cells where different reactions including S -nitrosylation, S -transnitrosation, and S -glutathionylation are involved (Hogg, S -nitrosylation as this kind of post-translational modification can alter the function of the affected proteins (Astier et al., Figure 1 1 -SH) through a process of S -transnitrosation between proteins

It sounds great, it looks great, but it smells a little fishy
