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We found that soluble ER residents in the core were concentrated toward the axis (Fig 12B), and ER residents within germ cells were concentrated near the core-facing surface of the nuclear envelope (inset, Fig 12B)

This peptide has been utilized in preclinical studies examining MC1R receptor binding kinetics, melanogenesis signaling pathways, eumelanin production mechanisms in melanocyte cell models, and photoprotective cellular response dynamics independent of the broader pigmentation effects associated with endogenous -MSH activity

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Treatments are therefore targeted at both the underlying inflammation and the repair and maintenance of the epidermal structures