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Bianco et al., 2019)

KPV exerts its primary anti-inflammatory activity through direct intracellular penetration of immune cells and intestinal epithelial cells, where it suppresses NF-B transcription factor activity the master regulator of pro-inflammatory cytokine gene expression through a receptor-independent intracellular mechanism, resulting in downstream reduction of IL-6, IL-8, TNF-, and related inflammatory mediators

Here's what often kicks in first: Within 1-3 days: Energy and alertness

Methylcobalamin - this is a naturally occuring and highly bio-available co-enzyme form of B12 and is found in natural food sources and is a highly bio-available form

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PMID 19707742