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In males, early testosterone depletion has been identified as a risk factor for early-onset AD, with lower testosterone levels frequently linked to cognitive impairment [180]

Mitochondria possess intrinsic antioxidant defenses that limit superoxide accumulation and preserve membrane integrity

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Using neuroproteomic approaches, we can also better characterize brain region-specific alterations that contribute to neural dysfunction and cognitive impairments with conditions ranging from normal aging to neurodegenerative diseases