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10.1016/j.freeradbiomed.2016.04.013 23 DeianaM.RosaA.CasuV.PigaR.Assunta DessM.AruomaO

Oral glucose tolerance tests performed in clinical trials showed no significant changes in glucose handling, and fasting insulin levels remained stable throughout treatment periods

In addition, it has been shown that melatonin can prevent oxaliplatin-induced neuronal apoptosis in rats by increasing the LC3A/3B autophagy pathway in peripheral nerves and dorsal root ganglia (DRG), limit oxaliplatin-induced mitochondrial dysfunction and exert neuroprotective effects by inducing autophagy [45]

Further support of this hypothesis comes from work in drosophila suggesting that overexpressing antioxidant genes specifically in the neurons of wildtype flies reduces the amount of time sleeping (Hill et al., 2018)

doi: 10.1007/s10989-016-9551-7 121 XieYZhangYZhangLTZengSXGuoZBZhengBD

doi: 10.1210/jc.2003-030222 118 GrahamLDPedersenSKBrownGSHoTKassirZMoynihanATet al