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Why Is There a Lack of Long-Term Human Safety Data

In a 12-week, randomized, double-blind, placebo-controlled trial (RCT) in active RA (Clinicaltrials.gov: NCT04068246, n=120) demonstrated that adjunct metformin (1000 mg/day) to methotrexate (MTX
Discher DE, Janmey P, Wang YL

Competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper

The Pyo Study (2007) Pyo et al
