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Maturitas 70 , 59 (2011)

Interestingly, WT + H 2 O 2 cells exhibited similar transcriptional changes (Supplementary Fig

Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides

At the cellular level, iron deficiency can disrupt mitochondrial ATP synthesis, reduce activity of tyrosine hydroxylase, monoamine oxidase, and other iron-dependent enzymes, compromise myelin synthesis, maturation of axons, and monoaminergic neurotransmission, affecting neuronal connectivity and cognitive development (Cheli et al

Effect of addition of GSH on the fluorescence intensity of FA-rGO-BSA/AuNCs Generally, GSH is found in the cytosol of cells where its concentration is in the range of 110 mM 69

Both chemotherapeutic agents (such as cisplatin and paclitaxel) and targeted therapeutic drugs (such as EGFR inhibitors and BRAF inhibitors) can induce resistant phenotypes in cancer cells after prolonged use ( 1.2 The unique significance of ferroptosis Ferroptosis was formally defined in 2012 as a form of regulated cell death that depends on iron ions and is triggered by the accumulation of lipid peroxides ( For instance, in drug-resistant lung adenocarcinoma, ferroptosis sensitivity is markedly enhanced due to upregulated ACSL4 expression and metabolic reprogramming, which synergize with immune crosstalksuch as CD8+ T cell-derived IFN-to overcome therapy resistance ( Notably, specific cancer subtypessuch as triple-negative breast cancer, lung adenocarcinoma, clear cell renal carcinoma, and mesenchymal-type tumors with high metastatic potentialexhibit heightened susceptibility to ferroptosis due to their inherent metabolic reprogramming, iron overload, and antioxidant system deficiencies