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Given the many unknowns with high dose folic acid supplementation, particularly unmetabolized folic acid (as covered in my folate article), Im not able to draw any strong conclusions here

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doi: 10.1016/j.ijpharm.2018.10.029

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Thus, in situ produced microbial folate may favourably influence the cellular nutrition of the local colonocytes and may be important in maintaining intestinal homeostasis and modulating gut microbiome function, e.g., through regulation of colon mucosal proliferation (i.e., colorectal cancer prevention) and its anti-inflammatory effects 248,249,256,257,277,278,279,280,281,282,283,284,285,286