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Misfolded peptides and oxidized damaged proteins are mainly degraded by the ubiquitinproteasome system and the autophagylysosomal pathway [107]

Shah, S

Upon activation, microglia drive neuroinflammation through the release of mediators, including tumor necrosis factor-alpha (TNF-), interleukin-1 alpha (IL-1), and complement component 1q (C1q), which promote the conversion of astrocytes into a neurotoxic A1-reactive phenotype (Tastan and Heneka, 2024)

"Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle"

However, the patient experienced weight gain during this period as an adverse reaction (Figure 2, Table 2, and Appendices C-M)
