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Ferroptosis is a non-apoptotic form of regulated cell death driven by iron-dependent lipid peroxidation, primarily occurring within cells

this design enables GSH-triggered drug release, confirmed by our in vitro release studies, and strong fluorescence from the SNCDs that supports optical tracking

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While polymorphisms in UGT , CYP , SULT and GST genes are well established [22,23,8992] and might affect the response to acetaminophen, only polymorphisms in UGT genes have been widely studied in relation to APAP pharmacokinetics in humans [20,23,26,93]

In animal studies, this change inhibits detoxification, depletes glutathione levels, and increases inflammation