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6 Core characteristics, distribution, and phenotypic plasticity of microglia 6.1 Microglial heterogeneity, activation signaling, and biphasic regulation in neurodegeneration Microglia, which constitute 1015% of brain cells, play a critical role in the innate immune response and neuroplasticity (Figure 3)

Excessive ROS accumulation not only causes membrane damage but also induces mitochondrial DNA damage, alters gene expression, and promotes muscle atrophy

Fujimoto, N., Onodera, H., Mitsumori, K., Tamura, T., Maruyama, S

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