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Given the important roles of IGF-IR in tumor progression, inhibition of IGF-IR activity has been proposed as a therapeutic strategy for solid tumors and hematologic malignancies [20]

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These data could provide a sound basis to develop a simple, safe, and inexpensive nutritional intervention to improve glutathione production and reduce oxidant damage in aging humans

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Studies carried out in the last few years have provided evidence that the development of a clinically-relevant leukemic disease implies a process of clonal evolution, starting from pre-leukemic clones that contain only some of the genetic alterations observed at the level of leukemic cells (Fig

Arch Dermatol Res 296(4):169174