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Transforming growth factor-1 (TGF-1) can induce the EMT phenotype in melanoma cells and upregulate the levels of GPX4 and SLC7A11, while gambogenic acid, a xanthone derived from traditional Chinese medicine Gamboge, can promote ferroptosis by inhibiting the SLC7A11/GPX4 pathway in melanoma cells stimulated by TGF-1

[PubMed] [Google Scholar] Cerovecki T., Bojanic I., Brcic L., Radic B., Vukoja I., Seiwerth S., et al

In such cases, I believe that it is prudent to administer acetylcysteine to any patient who may have taken an overdose and who has a measurable acetaminophen concentration until risk stratification can be performed (i.e., until the time of ingestion is determined), until the patient meets the criteria for stopping, or until the course is completed