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Yang NC, Lin HC, Wu JH, et al
In clinical trials of semaglutide injection for weight management, patients treated with semaglutide had a mean increase from baseline in amylase of 16% and lipase of 39%

Cell Biol Toxicol 35 (5), 407421

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In the absence of charge effects, the reaction will occur at the site where the greatest overlap can occur between the HOMO of the nucleophile the LUMO of the electrophile