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It was developed from angiotensin IV by the Harding group, which was studying angiotensin IVs cognitive effects

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in its active form (thiamine diphosphate), it is an essential cofactor for enzymes in glucose and amino acid catabolism, helping convert nutrients into ATP and supporting normal neuronal function

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Elevated Bcl-2/Bax ratios and reduced cleaved PARP confirmed the anti-apoptotic effect (Pyo et al., 2007)

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