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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Zang J, Cui M, Xiao L, Zhang J, Jing R

It has been demonstrated to possess a variety of biological activities, including substantial anti-inflammatory and anti-tumor properties, as well as the capacity to modulate immune function and inhibit the growth of pathogenic microorganisms ( 3.4 Flavonoids Flavonoids such as quercetin, kaempferol, myricetin, apigenin, baicalin, luteolin, hesperidin, genistein, proanthocyanidins, and kaempferol exert multi-targeted and multi-pathway effects in DKD therapy, demonstrating the significant therapeutic potential of certain flavonoids for DKD ( 3.4.1 Quercetin Quercetin is a natural flavonoid found in large quantities in vegetables and fruits, mainly in the form of glycosides, with anti-inflammatory, antiviral and antioxidant properties

Lactate buildup at the site of chronic inflammation promotes disease by inducing CD4 + T cell metabolic rewiring

CSVD: Cerebral Small Vessel Disease

Insulin resistance constitutes an important mechanistic link between prolactin abnormalities and obesity-related metabolic disorders, and is a core pathological feature of metabolic syndrome and type 2 diabetes (49)