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In addition, clinical risk factors such as dyslipidemia, hypertension, and hyperglycemia should be addressed more aggressively

8388 A completed Phase I/IIA multicenter dose-ranging clinical trial that sought to assess the safety and efficacy of TLK286 found that the compound was highly efficacious

Although there is evidence that prepro-TRH 178-199 can inhibit both basal and CRH-stimulated ACTH release in AtT-20 cell lines and rat anterior pituitary cells (136,137), other investigators have not been able to confirm this (138)

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Neurogastroenterol Motil 29(7):e13037 Soleimani A, Motamedzadeh A, Zarrati Mojarrad M, Bahmani F, Amirani E, Ostadmohammadi V, Tajabadi-Ebrahimi M, Asemi Z (2019) The effects of synbiotic supplementation on metabolic status in diabetic patients undergoing hemodialysis: a randomized, double-blinded, placebo-controlled trial

Given that statin-induced cell death featured multiple hallmarks of ferroptosis, we also performed RNA sequencing on the same cell lines treated with RSL3 to determine the transcriptional changes associated with ferroptosis induction in these cells