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This has happened before, at least twice, and when it has it has represented periods in time where anti-doping and regulators were scrambling to catch up to illegal drugs or substances that had become mainstream

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1 The prevalence is 70% in Kenyan school children, 80% in East Indian preschool-aged children, and 70% in East Indian adults

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Very low or high blood levels of homocysteine can indicate a B12, folate, and/or B6 deficiency (21)