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MOTS-C essentially mimics one of the protective signals that estrogen used to help maintain

Eur J Pharmacol 730:2630

Nature 539 (7628), 294298

After 24 h, the culture medium was replaced with complete medium and 0.0250.250 ml of Lenti-X 293 T supernatant containing lentiviral particles and 4 g/ml of polybrene (hexadimethrine bromide, Sigma-Aldrich, Milan, Italy), per well

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Mass spectrometry data have been deposited in ProteomeXchange with the primary accession code PXD051110 ( Human PDA survival data were derived from KMPlot ( The dataset derived from this resource that supports the findings of this study is available at All other data supporting the findings of this study are available from the corresponding author on reasonable request