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[DOI] [PMC free article] [PubMed] [Google Scholar] 81.Levitt MD, Levitt DG

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These concerns necessitate further research, including dedicated long-term safety studies in animal models, specifically designed to assess potential risks associated with higher doses and prolonged exposure

For those with chronic absorption issues like pernicious anemia , lifelong injections every 2 to 3 months are common

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Negative response, meaning visible worsening or persistent adverse effects, warrants discontinuation and reassessment