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Moreover, the microbial dysbiosis index (MDI) was significantly correlated with both the severity and mortality of pneumonia ( Figure 1 2.2 Dysbiosis of the gut microbiota may impact pulmonary inflammation Dysbiosis of the gut microbiota can alter the lung microbiota, exacerbate lung inflammation, and even serve as a negative prognostic factor for pulmonary infections

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doi: 10.1016/j.toxrep.2019.11.007

While not all patients are candidates for lower-HFA alternatives, transitioning those who do qualify has the potential to significantly impact the negative climate-inhaler cycle