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This Phase 2b failure effectively terminated clinical development for obesity

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Methionine is converted into SAM by a process that requires energy

This knowledge guides appropriate mitigation strategies

Since adipose tissue is responsive to endotoxins, bacterial translocation may provide a mechanism whereby the gut microbiome can modulate the adipose metabolome (for review, Kruis et al., 2014 23 ) and consequently exacerbate obesity and its related comorbidities

TB-500 regulates actin polymerization, enabling cell migration and cytoskeletal remodeling during tissue repair