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For example, the endoplasmatic reticulum has a more oxidizing environment (E GSSG/2GSH = 180 mV) with respect to the cytosol (E GSSG/2GSH = 232 mV) in order to support and ensure proper protein folding and formation of necessary disulfide bridges [108,157]

Ann Pediatr Endocrinol Metab 27(4):256264

[DOI] [PubMed] [Google Scholar] 89.Perez MJ, Briz O

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As was concluded by Prabhu and Lei, both Se deficiency and oversupply seem to dysregulate glucose metabolism and potentiate the risk of type 2 diabetes in several animal studies, with less clear associations discovered in clinical studies [34]