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10.1126/science.aay8477 Science 70 MayerJ

Mechanisms of Action (Preclinical) Angiogenesis: the combination supports new blood vessel formation via VEGF, FGF, and TGF- pathways, enhancing oxygenation and nutrient delivery to stressed tissues in research models

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Collectively, these multifaceted disruptions lead to persistent hyperarousal, characterized by an imbalance between arousal-promoting neuronal circuits (e.g., the locus coeruleus and hypothalamic orexin neurons) and sleep-promoting circuits (e.g., the VLPO and basal forebrain)

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Intestinal Epithelial Serotonin as a Novel Target for Treating Disorders of Gut-Brain Interaction and Mood