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One of the widely used clinical tools for detecting neuropathy during chemotherapy is the National Cancer Institute Common Terminology Criteria for Adverse Events (NCI-CTCAE), but it is was not specifically developed to assess pain, is not sensitive to change and has significant inter-rater variability[19]

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This narrative review elucidates the effects of viral hijack on host cellular machinery during SARS-CoV-2 infection, ensuing detrimental effect(s) of virus-induced HMRD on human metabolism, consequential symptomatic clinical implications, and damage to multiple organ systems

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Moreover, we describe recent findings obtained by the study of Down syndrome (DS) neuropathology, which represents a unique opportunity to analyze the combined scenario of a genetic form of both OS and AD