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however, significant safety concerns regarding joint safety have emerged from these trials, where composite joint safety events (such as rapidly progressive OA Type 1) occurred at a dosedependent, statistically higher rate with tanezumab compared with NSAIDs, though adverse events like abnormal peripheral sensation were typically mild and transient [359]

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For lipid peroxide evaluation, cells were incubated for another 30 min after being stained with BODIPY 581/591 C11 probe (2.5 M)

Witkiewitz and Vowles, 2018)
