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doi: 10.1111/febs.14813
The peroxisome proliferator-activated receptor gamma (PPAR) pathway-which regulates macrophage polarizationis suppressed, further favoring M1 polarization (95, 96)
N.Gomez-DezaJ.AttigJ.talekarM.et al
Toll-like receptor activity in patients with obstructive sleep apnea
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In another preclinical GBM study, the EGFR TKI gefitinib was effective in attenuating downstream MAPK/MEK/ERK activity, but concurrent inhibition of EGFR and IGF-1R/INSR was required to suppress Akt and induce apoptosis [105]
