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Although a meta-analysis in 2007 showed no significant effect of l-arginine on PE prevention (RR: 0.83 [0.491.41]) [95], a recent meta-analysis in 2021 showed a preventive effect on PE reduction (RR: 0.38 0.250.58) (2 studies, n = 524) in women in the second and third trimesters, including women at high risk for PE [96]

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