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A significant inhibition of the enzymatic activity has also been observed with the antihypertensive drug verapamil and the histamine H2 receptor antagonist cimetidine, although the clinical use of the latter is currently anecdotal [23,80]

Because of the higher doses in many long-acting formulations, these drugs have a higher risk of serious adverse effects (eg, death due to respiratory depression) in opioid-naive patients

doi: 10.1186/1472-6882-13-253

Inconsistent dosing or self-medication blurs cause and effect

The free radical theory of aging was proposed by Derham Harman

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