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van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, et al

Notably, the mortality rate of endometrial cancer has steadily increased annually by approximately 1% (Siegel et al., 2023) Despite the twofold increase in the incidence of ovarian cancer in developed nations, the cumulative mortality risk remains similar between developed and developing regions (Zhang et al., 2019)

Therefore, despite the presence of various cytotoxic effects associated with HEFB, the toxicity of its polysaccharide components appears to be minimal

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(US Medical Information, Teva Pharmaceuticals, North Wales, PA): Personal communication

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