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Folate intake should not exceed 1667 mcg DFE daily

Mutations in genes encoding astrocyte-specific proteins can lead either to loss of functions with subsequent secondary neural injury or to the emergence of aberrant cellular phenotypes damaging nervous tissue in yet unidentified manner

BioMed Research International 2021:9924314

Dosage: Up to 100 mg/day [8]

They all needed more than 2.1 g/day, with some subjects requiring up to 3.0 g/day to remain in positive nitrogen balance

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