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The rest rely on preclinical data alone

Guide for the Care and Use of Laboratory Animals , 8th ed, 220 (National Academies Press, 2011)

Again, Im not sure as to why certain people seem to respond better to B12 shots vs oral B12 supplements but its worth knowing

Most Common B12/MIC Side Effects Pain or redness at the injection site Itching or a feeling of swelling all over the body Muscle cramps & weakness Upset stomach & urinary problems Swelling in the ankles or feet Unusual tiredness If irritation continues to occur, apply an over-the-counter itch cream, preferably with hydrocortisone, or discontinue use entirely

By delivering vitamin B12 straight into your muscle tissue, your body can use 100% of the dose immediately