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The immune cells in these patients are dealing with such an extreme, unrelenting burden of oxidative stress and mitochondrial lipid damage that they have frantically ramped up their own internal glutathione production in a desperate attempt to survive

Thus, Gsr-mediated redox regulation is crucial for fungal clearance by neutrophils and the proper control of the inflammatory response by macrophages during host defense against fungal challenge

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doi: 10.1080/17425255.2017.1251580

Causes include vaginal atrophy, pelvic floor dysfunction, and structural changes post-childbirth

Neither spontaneous nor odor-induced firing frequency displayed circadian rhythms, suggesting that higher spike amplitudes might sensitize downstream neurons to produce a more robust response to stimulus in the middle of the night (Krishnan et al., 2008)