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To assess whether our in vitro system can monitor dose-dependent toxicity, we analyzed in a cohort of 50 individuals the effect of acetaminophen (APAP), a prototypical intrinsic DILI drug that causes predictable and dose-related toxicity in nearly all individuals at high concentrations(Figure 5A)

Food and Drug Administration (FDA) recalled the drug on April 20, 2024, as stated in the recall enforcement report

NICE guidance acknowledges that response to treatment varies between individuals

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