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Moreover, some NAD + precursors have shown side effects, such as the use of NA at certain doses that might be limited due to skin flushing or induction of insulin resistance 332,333

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doi: 10.3390/nu9010001, Summary Keywords vitamin B 12 , health care, hospitalization, public health burden, clinical diseases Citation de Carvalho LP, Akamine N, Di Pietro MS, Frana CN, Oliveira R and Lopes RD (2026) Vitamin B 12 deficiency and its impact on healthcare: a population-level analysis and call for action