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70 Although ibudilast did not significantly impact negative mood, it did reduce the odds of heavy drinking by 45% and attenuated alcohol cue-elicited activation in the ventral striatum (which is the brain region most closely associated with reward)

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Martin, E., Zhang, A., & Campiche, R

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These compounds may remain detectable for 23 weeks or longer, depending on injection dose, frequency, and test method