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Best Forms of B12 for MTHFR Not all B12 supplements are created equal, especially if you have an MTHFR gene mutation

These areas (upper arms, outer-upper thighs, and belly area) have fewer blood vessels than muscle, which allows nutrients to absorb more slowly and consistently over time

The B6 component acts as a natural diuretic, helping alleviate hormonally-mediated fluid retention and bloating so you feel lighter and more comfortable

Methylcobalamin provides immediate bioavailability without requiring metabolic conversion, making it theoretically superior

Duration: 14 days

For each eligible study, two authors (MM and AN) independently extracted data, which was then reviewed by a third author (JV) using a piloted spreadsheet, in accordance with Cochrane Collaboration guidelines ( Where relevant data were missing, attempts were made to contact corresponding authors