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Formulation and delivery remain challenges

BMC Med 19:5 Williams TN (2021) Undernutrition: a major but potentially preventable cause of poor outcomes in children living with sickle cell disease in Africa

Two aspects of great importance to the pathophysiology discussed in this article are as follows: ( 1 ) -glutamylcysteine synthetase, the enzyme driving the first reaction, is normally inhibited by physiologic concentrations of the downstream product glutathione (this inhibition is shown by the broken blue line in Figure 1)

Kozina, L

This article walks through the per-compound adverse-event profiles, what the combination plausibly looks like based on mechanism and analog data, and the community-reported pattern of effects on the staged titration protocol

AOD-9604 is supplied as a research grade synthetic peptide reference compound intended exclusively for controlled laboratory and analytical environments