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If HE is present, then lactulose (0.25-2 ml/kg to effecting soft stools), plus metronidazole (7.5 mg/kg PO q12h) are indicated

Early research suggested that loading creatine at a total of 25 grams per day (split into five servings) for a week followed by reducing the dosage to five grams a day thereafter was the most effective protocol

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194 CoQ10 may be synergistic with curcumin, as one study ( n = 100) found that a combination of curcumin (80 mg) plus CoQ10 (300 mg) was significantly more effective than either therapy alone for migraine prevention